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Unbiased screening identifies regulators of cell-cell adhesion and treatment options in pemphigus

Abstract Cell-cell junctions, and specifically desmosomes, are crucial for robust intercellular adhesion. Desmosomal function is compromised in the autoimmune blistering skin disease pemphigus vulgaris. We combine whole-genome knockout screening and a promotor screen of the desmosomal gene desmoglei...

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Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Henriette Franz, Maitreyi Rathod, Aude Zimmermann, Chiara Stüdle, Vivien Beyersdorfer, Karen Leal-Fischer, Pauline Hanns, Tomás Cunha, Dario Didona, Michael Hertl, Marion Scheibe, Falk Butter, Enno Schmidt, Volker Spindler
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Nature Portfolio 2024-09-01
Sraith:Nature Communications
Rochtain ar líne:https://doi.org/10.1038/s41467-024-51747-2
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