Neutralizing human monoclonal antibodies that target the PcrV component of the type III secretion system of Pseudomonas aeruginosa act through distinct mechanisms

Pseudomonas aeruginosa is a major human opportunistic pathogen associated with a high incidence of multi-drug resistance. The antibody-based blockade of P. aeruginosa virulence factors represents a promising alternative strategy to mitigate its infectivity. In this study, we employed single B cell s...

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Auteurs principaux:	Jean-Mathieu Desveaux, Eric Faudry, Carlos Contreras-Martel, François Cretin, Leonardo Sebastian Dergan-Dylon, Axelle Amen, Isabelle Bally, Victor Tardivy-Casemajor, Fabien Chenavier, Delphine Fouquenet, Yvan Caspar, Ina Attree, Andrea Dessen, Pascal Poignard
Format:	Artigo
Langue:	Inglês
Publié:	eLife Sciences Publications Ltd 2026-02-01
Collection:	eLife
Sujets:	Pseudomonas aeruginosa B cell Antibody virulence factors T3SS
Accès en ligne:	https://elifesciences.org/articles/105195
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