Bone-targeting exosome nanoparticles activate Keap1 / Nrf2 / GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells

Abstract Background In recent years, the development of BMSCs-derived exosomes (EXO) for the treatment of osteosarcoma (OS) is a safe and promising modality for OS treatment, which can effectively deliver drugs to tumor cells in vivo. However, the differences in the drugs carried, and the binding of...

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Detalhes bibliográficos

Principais autores:	Wenkai Chen, Zongguang Li, Naichun Yu, Linlin Zhang, Hongyu Li, Yongjie Chen, Fengqing Gong, Wenping Lin, Xu He, Siyuan Wang, Yue Wu, Guangrong Ji
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-09-01
coleção:	Journal of Nanobiotechnology
Assuntos:	Homologous targeting Ferroptosis Osteosarcoma Chemotherapy Nrf2
Acesso em linha:	https://doi.org/10.1186/s12951-023-02129-1
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