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Development of a Cationic Polymeric Micellar Structure with Endosomal Escape Capability Enables Enhanced Intramuscular Transfection of mRNA-LNPs

<b>Background/Objectives:</b> The endosomal escape of lipid nanoparticles (LNPs) is crucial for efficient mRNA-based therapeutics. Here, we present a cationic polymeric micelle (cPM) as a safe and potent co-delivery system with enhanced endosomal escape capabilities. <b>Methods:</b> We synthesized a...

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Principais autores: Siyuan Deng, Han Shao, Hongtao Shang, Lingjin Pang, Xiaomeng Chen, Jingyi Cao, Yi Wang, Zhao Zhao
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-12-01
Serier:Vaccines
Fag:
mRNA-LNP
cationic polymeric micelle
endosomal escape
transfection efficiency
Online adgang:https://www.mdpi.com/2076-393X/13/1/25
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