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Overexpression of KIAA1199, a novel strong hyaluronidase, is a poor prognostic factor in patients with osteosarcoma

Abstract Background Hyaluronan (HA) has been shown to play important roles in the growth, invasion, and metastasis of malignant tumors. KIAA1199, which has potent HA-degrading activity, has been reported to be expressed in various malignancies and associated with patient prognosis. However, there ar...

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Principais autores: Kan Ito, Yoshihiro Nishida, Kunihiro Ikuta, Hiroshi Urakawa, Hiroshi Koike, Tomohisa Sakai, Jiarui Zhang, Yoshie Shimoyama, Shiro Imagama
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2021-07-01
Serier:Journal of Orthopaedic Surgery and Research
Fag:
Osteosarcoma
KIAA1199
Hyaluronan
Prognostic factor
Immunostaining
Online adgang:https://doi.org/10.1186/s13018-021-02590-4
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