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Mitochondrial protein OPA1 is required for the expansion of effector CD8 T cells

Summary: Short-lived effector cells are characterized metabolically by a highly glycolytic state, driving energy and biomass acquisition, whereas memory-fated T cells have historically been described as meeting these requirements through mitochondrial metabolism. Here, we show that the mitochondrial...

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Bibliografische Detailangaben
Hauptverfasser: Benjamin A.S. Willett, Scott B. Thompson, Vincent Chen, Anza Dareshouri, Conner L. Jackson, Tonya Brunetti, Angelo D’Alessandro, Jared Klarquist, Travis Nemkov, Ross M. Kedl
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2025-05-01
Schriftenreihe:Cell Reports
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Online-Zugang:http://www.sciencedirect.com/science/article/pii/S221112472500381X
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