The beta secretase BACE1 regulates the expression of insulin receptor in the liver

A soluble form of insulin receptor in human plasma has been previously reported. Here the authors demonstrate that insulin receptor is cleaved by BACE1 that can regulate biological active insulin receptor levels in a glucose concentration-dependent manner, both in physiological and diabetic conditio...

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Detalhes bibliográficos

Principais autores:	Paul J. Meakin, Anna Mezzapesa, Eva Benabou, Mary E. Haas, Bernadette Bonardo, Michel Grino, Jean-Michel Brunel, Christèle Desbois-Mouthon, Sudha B. Biddinger, Roland Govers, Michael L. J. Ashford, Franck Peiretti
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2018-04-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-018-03755-2
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