The deubiquitinase USP35: from an oncogenic hub to a therapeutic target in human cancers

Ubiquitination is a critical post-translational modification in eukaryotic cells, mediated by a sequential enzymatic cascade involving E1 (activating), E2 (conjugating), and E3 (ligase) enzymes that catalyze the covalent conjugation of ubiquitin to substrate proteins. This modification precisely con...

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Bibliografski detalji

Glavni autori:	Bisheng Li, Yuhong Wen, Rubin Wang, Jianhua Xiao, Wenjie Liao, Yihao Liao, Honggang Yuan
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2026-05-01
Serija:	Frontiers in Oncology
Teme:	deubiquitinase molecular target tumor progression ubiquitination USP35
Online pristup:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1825797/full
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