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Dehydration promotes intracellular lipid synthesis and accumulation

Abstract Lipids can be considered a water reservoir used to offset dehydration stress as their oxidation by the mitochondria generates water. However, whether dehydration and the ensuing hypertonic stress directly regulate lipid synthesis is unknown. We show that hypertonic stress decreases cellular...

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Principais autores: Joshua S. Carty, Jazlyn Selvasingh, Yvonne Zuchowski, Hyuck-Jin Nam, Clothilde Pénalva, Gayani Nanayakkara, Erin Q. Jennings, Kelsey Voss, Edith T. Adame, John T. Tossberg, Wei Sheng Yap, Meiling Melzer, Olga Viquez, A. Scott McCall, Elizabeth R. Piotrowski, Ryoichi Bessho, Shirong Cao, Katrina L. Leaptrot, Alexandra C. Schrimpe-Rutledge, Simona G. Codreanu, Stacy D. Sherrod, John A. McLean, Jonathan B. Trapani, Matthew A. Cottam, Ma Wan, Deepti Shrivastava, Don A. Delker, Matthew H. Wilson, Clinton M. Hasenour, Louise Lantier, Irene Chernova, Jamey D. Young, Volker H. Haase, Jose Pablo Vazquez-Medina, Dylan K. Kosma, Peter K. Kim, Jean-Philippe Cartailler, Mingzhi Zhang, Roy Zent, Raymond C. Harris, Jason A. Watts, Andrew S. Terker, Fabian Bock, Jeffrey C. Rathmell, Aylin R. Rodan, Juan P. Arroyo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2026-05-01
coleção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-026-73534-x
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