In situ generation, metabolism and immunomodulatory signaling actions of nitro-conjugated linoleic acid in a murine model of inflammation

Conjugated linoleic acid (CLA) is a prime substrate for intra-gastric nitration giving rise to the formation of nitro-conjugated linoleic acid (NO2-CLA). Herein, NO2-CLA generation is demonstrated within the context of acute inflammatory responses both in vitro and in vivo. Macrophage activation res...

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Auteurs principaux:	Luis Villacorta, Lucia Minarrieta, Sonia R. Salvatore, Nicholas K. Khoo, Oren Rom, Zhen Gao, Rebecca C. Berman, Soma Jobbagy, Lihua Li, Steven R. Woodcock, Y. Eugene Chen, Bruce A. Freeman, Ana M. Ferreira, Francisco J. Schopfer, Dario A. Vitturi
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2018-05-01
Collection:	Redox Biology
Sujets:	Nitro-fatty acid Electrophile Inflammation Macrophage Nrf2 NF-κB Nitration
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2213231717309552
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