Urolithin A-mediated augmentation of intestinal barrier function through elevated secretory mucin synthesis

Abstract Maintaining the mucus layer is crucial for the innate immune system. Urolithin A (Uro A) is a gut microbiota-derived metabolite; however, its effect on mucin production as a physical barrier remains unclear. This study aimed to elucidate the protective effects of Uro A on mucin production i...

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Bibliografiske detaljer

Principais autores:	Takeshi Yasuda, Tomohisa Takagi, Kohei Asaeda, Hikaru Hashimoto, Mariko Kajiwara, Yuka Azuma, Hiroaki Kitae, Yasuko Hirai, Katsura Mizushima, Toshifumi Doi, Ken Inoue, Osamu Dohi, Naohisa Yoshida, Kazuhiko Uchiyama, Takeshi Ishikawa, Hideyuki Konishi, Yuichi Ukawa, Akiko Kohara, Masatake Kudoh, Ryo Inoue, Yuji Naito, Yoshito Itoh
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2024-07-01
Serier:	Scientific Reports
Fag:	Urolithin A Mucin 2 production AhR signaling Nrf2 pathway Intestinal barrier function Colitis prevention
Online adgang:	https://doi.org/10.1038/s41598-024-65791-x
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