Targeted gene sequencing and transcriptome sequencing reveal characteristics of NUP98 rearrangement in pediatric acute myeloid leukemia

Abstract Background NUP98 rearrangements (NUP98-r) are rare but overrepresented mutations in pediatric acute myeloid leukemia (AML) patients. NUP98-r is often associated with chemotherapy resistance and a particularly poor prognosis. Therefore, characterizing pediatric AML with NUP98-r to identify a...

Полное описание

Библиографические подробности

Главные авторы:	Jing-Ying Zhang, Chun-Rong Chen, Jia-Yue Qin, Di-Ying Shen, Li-Xia Liu, Hua Song, Tian Xia, Wei-Qun Xu, Yan Wang, Feng Zhu, Mei-Xin Fang, He-Ping Shen, Chan Liao, Ao Dong, Shan-Bo Cao, Yong-Min Tang, Xiao-Jun Xu
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2024-09-01
Серии:	European Journal of Medical Research
Предметы:	NUP98 rearrangement Acute myeloid leukemia Molecular characteristics Clinical features Targeted next-generation sequencing
Online-ссылка:	https://doi.org/10.1186/s40001-024-02042-9
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