NHEJ and HDR can occur simultaneously during gene integration into the genome of Aspergillus niger

Abstract Non-homologous end joining (NHEJ) and homology-directed repair (HDR) are two mechanisms in filamentous fungi to repair DNA damages. NHEJ is the dominant response pathway to rapidly join DNA double-strand breaks, but often leads to insertions or deletions. On the other hand, HDR is more prec...

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Egile Nagusiak:	Susanne Fritsche, Aline Reinfurt, Felix Fronek, Matthias G. Steiger
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	BMC 2024-08-01
Saila:	Fungal Biology and Biotechnology
Gaiak:	DNA repair CRISPR/Cas9-mediated genome editing DNA modification Homology-directed repair Non-homologous end joining Self-replicating plasmid
Sarrera elektronikoa:	https://doi.org/10.1186/s40694-024-00180-7
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