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Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals

IFIT (interferon-induced with tetratricopeptide repeats) proteins are critical mediators of mammalian innate antiviral immunity. Mouse IFIT1 selectively inhibits viruses that lack 2'O-methylation of their mRNA 5' caps. Surprisingly, human IFIT1 does not share this antiviral specificity. Here, we res...

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Principais autores: Matthew D Daugherty, Aaron M Schaller, Adam P Geballe, Harmit S Malik
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2016-05-01
Serier:eLife
Fag:
innate immunity
mRNA modification
translation
gene conversion
phylogeny
host-virus interactions
Online adgang:https://elifesciences.org/articles/14228
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