LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion
Insulin secretion by β-cells is stimulated by glucose and is dependent on the induction of β-cell membrane depolarization, mainly driven by the closure of KATP channels, which in turn promotes voltage-gated Ca2+ channel opening. Here the authors show that LRRC8 volume-regulated anion channels (VRACs...
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| Principais autores: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Portfolio
2018-05-01
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| Series: | Nature Communications |
| Acceso en liña: | https://doi.org/10.1038/s41467-018-04353-y |
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