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Impaired flux of bile acids from the liver to the gut reveals microbiome-immune interactions associated with liver damage

Abstract Currently, there is evidence that alteration in the gut ecosystem contributes to the development of liver diseases, however, the complex mechanisms involved are still unclear. We induced cholestasis in mice by bile duct ligation (BDL), mirroring the phenotype of a bile duct obstruction, to...

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Auteurs principaux: Howell Leung, Ling Xiong, Yueqiong Ni, Anne Busch, Michael Bauer, Adrian T. Press, Gianni Panagiotou
Format: Artigo
Langue:Inglês
Publié: Nature Portfolio 2023-06-01
Collection:npj Biofilms and Microbiomes
Accès en ligne:https://doi.org/10.1038/s41522-023-00398-0
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