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Distinct immune properties of the N- and C-termini of the immunosuppressive domain of Ebola virus glycoprotein

ABSTRACT Ebola virus (EBOV) causes a severe human disease with high lethality. Pathogenesis of EBOV disease is characterized by a paradoxical combination of hyperinflammation and immunosuppression. EBOV has a single envelope glycoprotein (GP), which is a type I transmembrane protein with strong immu...

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Principais autores: Mathieu Iampietro, Sivakumar Periasamy, Philipp A. Ilinykh, Yuan Qiu, Yakun Liu, Abhinit Nagar, Bin Gong, Alexander Bukreyev
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2025-11-01
coleção:mBio
Assuntos:
ebola virus
cytokine
immunosuppression
inflammation
Acesso em linha:https://journals.asm.org/doi/10.1128/mbio.02278-25
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