Nivolumab plus ipilimumab and cobimetinib in previously treated microsatellite-stable/DNA mismatch repair-proficient metastatic colorectal cancer: the phase II CheckMate 142 trial

Background: Immune checkpoint inhibitors (ICIs) have shown limited efficacy in patients with microsatellite-stable/DNA mismatch repair-proficient (MSS/pMMR) metastatic colorectal cancer (CRC). Based on data suggesting antitumor synergy between ICIs and MEK inhibitors, the phase II CheckMate 142 tria...

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Bibliografische Detailangaben

Hauptverfasser:	M.J. Overman, S. McCraith, B. He, L. Jin, M. Lei, J. Yao, M.A. Morse
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2026-06-01
Schriftenreihe:	ESMO Gastrointestinal Oncology
Schlagworte:	nivolumab ipilimumab cobimetinib metastatic colorectal cancer MSS/pMMR
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2949819826000348
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