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Activation of PKCε-ALDH2 Axis Prevents 4-HNE-Induced Pain in Mice

Protein kinase Cε (PKCε) is highly expressed in nociceptor neurons and its activation has been reported as pro-nociceptive. Intriguingly, we previously demonstrated that activation of the mitochondrial PKCε substrate aldehyde dehydrogenase-2 (ALDH2) results in anti-nociceptive effects. ALDH2 is a ma...

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Principais autores: Bárbara B. Martins, Natália G. Hösch, Queren A. Alcantara, Grant R. Budas, Che-Hong Chen, Daria Mochly-Rosen, Julio C. B. Ferreira, Vanessa O. Zambelli
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-11-01
Serier:Biomolecules
Fag:
oxidative stress
neuroprotection
protein kinase
neurodegeneration
hyperalgesia
Online adgang:https://www.mdpi.com/2218-273X/11/12/1798
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