Pleomorphic effects of three small-molecule inhibitors on transcription elongation by Mycobacterium tuberculosis RNA polymerase

The Mycobacterium tuberculosis RNA polymerase (MtbRNAP) is the target of the first-line anti-tuberculosis inhibitor rifampin; however, the emergence of rifampin resistance necessitates the development of new antibiotics. Here, we communicate the first single-molecule characterization of MtbRNAP elon...

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Autors principals:	Omar Herrera-Asmat, Alexander B Tong, Wenxia Lin, Tiantian Kong, Juan R Del Valle, Daniel G Guerra, Yon W Ebright, Richard H Ebright, Carlos Bustamante
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2025-10-01
Col·lecció:	eLife
Matèries:	M. tuberculosis single molecule biophysics optical tweezers transcription antibiotics
Accés en línia:	https://elifesciences.org/articles/105545
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