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Environmental stimulation in Huntington disease patients and animal models

While Huntington disease (HD) is caused solely by a polyglutamine expansion in the huntingtin gene, environmental factors can influence HD onset and progression. Here, we review studies linking environment and HD in both humans and animal models. In HD patients, we find that: (i) an active lifestyle...

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Autors principals: Arianna Novati, Huu Phuc Nguyen, Julia Schulze-Hentrich
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2022-09-01
Col·lecció:Neurobiology of Disease
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Accés en línia:http://www.sciencedirect.com/science/article/pii/S0969996122001176
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