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FCoR-Foxo1 Axis Regulates α-Cell Mass through Repression of Arx Expression

Summary: Pancreatic endocrine cell development into differentiated α- and β-cells is highly regulated and involves multiple transcription factors. However, the mechanisms behind the determination of α- and β-cell masses remains unclear. We previously identified Foxo1 CoRepressor (FCoR), which inhibi...

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Huvudupphov: Noriko Kodani, Jun Nakae, Masaki Kobayashi, Osamu Kikuchi, Tadahiro Kitamura, Hiroshi Itoh
Materialtyp: Artigo
Språk:Inglês
Utgiven: Elsevier 2020-01-01
Serie:iScience
Länkar:http://www.sciencedirect.com/science/article/pii/S2589004219305449
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