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FGF8–FGFR1 signaling regulates human GnRH neuron differentiation in a time- and dose-dependent manner

Fibroblast growth factor 8 (FGF8), acting through the fibroblast growth factor receptor 1 (FGFR1), has an important role in the development of gonadotropin-releasing hormone-expressing neurons (GnRH neurons). We hypothesized that FGF8 regulates differentiation of human GnRH neurons in a time- and do...

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Principais autores: Venkatram Yellapragada, Nazli Eskici, Yafei Wang, Shrinidhi Madhusudan, Kirsi Vaaralahti, Timo Tuuri, Taneli Raivio
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists 2022-08-01
Serier:Disease Models & Mechanisms
Fag:
hpscs
gnrh neuron
fgf8
fgfr1
transcriptome
Online adgang:http://dmm.biologists.org/content/15/8/dmm049436
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