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Lysosomal Enzyme Glucocerebrosidase Protects against Aβ1-42 Oligomer-Induced Neurotoxicity.

Glucocerebrosidase (GCase) functions as a lysosomal enzyme and its mutations are known to be related to many neurodegenerative diseases, including Gaucher's disease (GD), Parkinson's disease (PD), and Dementia with Lewy Bodies (DLB). However, there is little information about the role of GCase in th...

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Principais autores: Seulah Choi, Donghoon Kim, Tae-In Kam, Seungpil Yun, Sangjune Kim, Hyejin Park, Heehong Hwang, Olga Pletnikova, Juan C Troncoso, Valina L Dawson, Ted M Dawson, Han Seok Ko
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2015-01-01
coleção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC4668030?pdf=render
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