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The MAPT H1 Haplotype Is a Risk Factor for Alzheimer’s Disease in APOE ε4 Non-carriers

An ancestral inversion of 900 kb on chromosome 17q21, which includes the microtubule-associated protein tau (MAPT) gene, defines two haplotype clades in Caucasians (H1 and H2). The H1 haplotype has been linked inconsistently with AD. In a previous study, we showed that an SNP tagging this haplotype...

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Auteurs principaux: Pascual Sánchez-Juan, Sonia Moreno, Itziar de Rojas, Isabel Hernández, Sergi Valero, Montse Alegret, Laura Montrreal, Pablo García González, Carmen Lage, Sara López-García, Eloy Rodrííguez-Rodríguez, Adelina Orellana, Lluís Tárraga, Mercè Boada, Agustín Ruiz
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2019-12-01
Collection:Frontiers in Aging Neuroscience
Sujets:
Alzheimer’s disease
MAPT
H1H2
APOE
genetic association
Accès en ligne:https://www.frontiersin.org/article/10.3389/fnagi.2019.00327/full
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