Targeting lysyl oxidase like 2 attenuates OVA-induced airway remodeling partly via the AKT signaling pathway

Abstract Background Airway epithelium is an important component of airway structure and the initiator of airway remodeling in asthma. The changes of extracellular matrix (ECM), such as collagen deposition and structural disturbance, are typical pathological features of airway remodeling. Thus, ident...

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Autori principali:	Rong Zeng, Dong Zhang, Jintao Zhang, Yun Pan, Xiaofei Liu, Qian Qi, Jiawei Xu, Changjuan Xu, Shuochuan Shi, Junfei Wang, Tian Liu, Liang Dong
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2024-06-01
Serie:	Respiratory Research
Soggetti:	Asthma Airway remodeling LOXL2 Extracellular matrix EMT
Accesso online:	https://doi.org/10.1186/s12931-024-02811-4
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