Counterfactual estimation of efficacy against placebo for novel PrEP agents using external trial data: example of injectable cabotegravir and oral PrEP in women

Abstract Introduction Multiple antiretroviral agents have demonstrated efficacy for human immunodeficiency virus (HIV) pre‐exposure prophylaxis (PrEP). As a result, clinical trials of novel agents have transitioned from placebo‐ to active‐controlled designs; however, active‐controlled trials do not...

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Autors principals:	Deborah Donnell, Fei Gao, James P. Hughes, Brett Hanscom, Lawrence Corey, Myron S. Cohen, Srilatha Edupuganti, Nyaradzo Mgodi, Helen Rees, Jared M. Baeten, Glenda Gray, Linda‐Gail Bekker, Mina Hosseinipour, Sinead Delany‐Moretlwe
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2023-06-01
Col·lecció:	Journal of the International AIDS Society
Matèries:	counterfactual placebo cabotegravir emtricitabine/tenofovir disoproxil fumarate HIV pre‐exposure prophylaxis efficacy trial design
Accés en línia:	https://doi.org/10.1002/jia2.26118
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