Pharmacological targeting of KDM6A and KDM6B, as a novel therapeutic strategy for treating craniosynostosis in Saethre-Chotzen syndrome

Abstract Background During development, excessive osteogenic differentiation of mesenchymal progenitor cells (MPC) within the cranial sutures can lead to premature suture fusion or craniosynostosis, leading to craniofacial and cognitive issues. Saethre-Chotzen syndrome (SCS) is a common form of cran...

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Auteurs principaux:	Clara Pribadi, Esther Camp, Dimitrios Cakouros, Peter Anderson, Carlotta Glackin, Stan Gronthos
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2020-12-01
Collection:	Stem Cell Research & Therapy
Sujets:	Epigenetics KDM6A KDM6B Calvarial cells Osteogenesis Coronal sutures
Accès en ligne:	https://doi.org/10.1186/s13287-020-02051-5
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