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A decrease in Fkbp52 alters autophagosome maturation and A152T-tau clearance in vivo

The failure of the autophagy-lysosomal pathway to clear the pathogenic forms of Tau exacerbates the pathogenesis of tauopathies. We have previously shown that the immunophilin FKBP52 interacts both physically and functionally with Tau, and that a decrease in FKBP52 protein levels is associated with...

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Principais autores: Emilie Lesport, Lucie Commeau, Mélanie Genet, Etienne-Emile Baulieu, Marcel Tawk, Julien Giustiniani
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2024-07-01
סדרה:Frontiers in Cellular Neuroscience
נושאים:
tau
tauopathies
lysosomes
autophagy
FKBP52
zebrafish
גישה מקוונת:https://www.frontiersin.org/articles/10.3389/fncel.2024.1425222/full
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