Discovery of co-stimulatory anti-CD28 VHHs for developing cancer immune therapeutic anti-tumor/CD3/CD28 trispecific T cell engager

IntroductionCD28 is a critical co-stimulatory receptor expressed on T cells. Alongside the T-cell receptor (TCR), it provides a dual-signal requirement that is necessary for the complete activation of T cells. Developing co-stimulatory agonists targeting CD28 therefore represents a promising strateg...

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Autori principali:	Hui Wang, Rui Zhao, Mengmeng Liu, Tianzhi Jiang, Di Sun, Lida Chi, Yonglin Huang, Zhenghui Lu, Yueli Yun, Xiangbin Wang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-04-01
Serie:	Frontiers in Immunology
Soggetti:	agonist CD28 co-stimulatory T cell engager VHH
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1812063/full
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