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Carvacrol ameliorates cyclophosphamide-induced rat premature ovarian failure and uterine fibrosis via regulating PI3K/AKT/FOXO3a signaling pathway

Abstract Background Premature ovarian failure (POF) and ovarian reserve loss are common problems associated with cancer therapies. Carvacrol (Carva) showed significant efficacies in ameliorating several toxicological impacts and complications associated with chemotherapeutic agents. Thus, this study...

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Principais autores: Zeinab A. El-Gendy, Seham Samir Soliman, Mohamed S. Aly, Sara M. Baraka
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-12-01
Serier:Journal of Ovarian Research
Fag:
Cyclophosphamide
Ovarian toxicity
Carvacrol
FOXO3a
Oxidative stress
Online adgang:https://doi.org/10.1186/s13048-025-01880-3
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