Insight on Mutation-Induced Resistance from Molecular Dynamics Simulations of the Native and Mutated CSF-1R and KIT.

The receptors tyrosine kinases (RTKs) for the colony stimulating factor-1, CSF-1R, and for the stem cell factor, SCFR or KIT, are important mediators of signal transduction. The abnormal function of these receptors, promoted by gain-of-function mutations, leads to their constitutive activation, asso...

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Principais autores:	Priscila Da Silva Figueiredo Celestino Gomes, Isaure Chauvot De Beauchêne, Nicolas Panel, Sophie Lopez, Paulo De Sepulveda, Pedro Geraldo Pascutti, Eric Solary, Luba Tchertanov
Formato:	Artigo
Idioma:	Inglês
Publicado:	Public Library of Science (PLoS) 2016-01-01
Series:	PLoS ONE
Acceso en liña:	http://europepmc.org/articles/PMC4965071?pdf=render
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