Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy

Abstract Background Ubiquitination is a basic post-translational modification for cellular homeostasis, and members of the conjugating enzyme (E2) family are the key components of the ubiquitin–proteasome system. However, the role of E2 family in colorectal cancer (CRC) is largely unknown. Our study...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Tong Shen, Ling-Dong Cai, Yu-Hong Liu, Shi Li, Wen-Juan Gan, Xiu-Ming Li, Jing-Ru Wang, Peng-Da Guo, Qun Zhou, Xing-Xing Lu, Li-Na Sun, Jian-Ming Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2018-07-01
coleção:	Journal of Hematology & Oncology
Assuntos:	Ubiquitin-conjugating E2 enzyme Autophagy Epithelial mesenchymal transition Metastasis Colorectal cancer
Acesso em linha:	http://link.springer.com/article/10.1186/s13045-018-0638-9
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!