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PreS1 deletions in genotype C HBV leads to severe hepatic inflammation and hepatocarcinogenesis via the IRE1-JNK axis

Background & Aims: Deletion of 15–21 nucleotides covering the preS1 start codon frequently occurs in patients with chronic HBV (CHB) with HBV genotype C and has been reported to be related to progression to hepatocellular carcinoma (HCC). However, the underlying mechanism causing the distinct ph...

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Hlavní autoři: Yu-Min Choi, Junghwa Jang, Dong Hyun Kim, Ziyun Kim, Eunseo Kim, Won Hyeok Choe, Bum-Joon Kim
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2025-03-01
Edice:JHEP Reports
Témata:
5ʹ preS1 deletions
ER stress
IRE1-JNK signaling
Lipogenesis
Apoptosis
Inflammation
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2589555924002787
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