Nanocrystalline Suspensions of Irbesartan Enhance Oral Bioavailability by Improving Drug Solubility and Leading Endocytosis Uptake into the Intestine

We attempted to design irbesartan nanocrystalline (IRB-NC) suspensions by the bead mill method, and we evaluated the bioavailability (BA) in the oral administration of the nanocrystalline drug. The mean particle size of the IRB-NC suspensions was approximately 140 nm, and the crystalline structure o...

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Detalhes bibliográficos

Principais autores:	Saori Deguchi, Fumihiko Ogata, Masaki Watanabe, Hiroko Otake, Naoki Yamamoto, Naohito Kawasaki, Noriaki Nagai
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2021-09-01
Colecção:	Pharmaceutics
Assuntos:	nanocrystalline intestinal absorption irbesartan solubility endocytosis
Acesso em linha:	https://www.mdpi.com/1999-4923/13/9/1404
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