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M2 macrophage-derived cathepsin S promotes peripheral nerve regeneration via fibroblast–Schwann cell-signaling relay

Abstract Background Although peripheral nerves have an intrinsic self-repair capacity following damage, functional recovery is limited in patients. It is a well-established fact that macrophages accumulate at the site of injury. Numerous studies indicate that the phenotypic shift from M1 macrophage...

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Principais autores: Eri Oshima, Yoshinori Hayashi, Zhen Xie, Hitoshi Sato, Suzuro Hitomi, Ikuko Shibuta, Kentaro Urata, Junjun Ni, Koichi Iwata, Tatsuo Shirota, Masamichi Shinoda
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-11-01
Serier:Journal of Neuroinflammation
Fag:
Macrophage
Schwann cells
Ephrin-B2
Cathepsin S
Peripheral nerve injury
Axon regeneration
Online adgang:https://doi.org/10.1186/s12974-023-02943-2
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