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The role of SLC12A family of cation-chloride cotransporters and drug discovery methodologies

The solute carrier family 12 (SLC12) of cation-chloride cotransporters (CCCs) comprises potassium chloride cotransporters (KCCs, e.g. KCC1, KCC2, KCC3, and KCC4)-mediated Cl− extrusion, and sodium potassium chloride cotransporters (N[K]CCs, NKCC1, NKCC2, and NCC)-mediated Cl− loading. The CCCs play...

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Autori principali: Shiyao Zhang, Nur Farah Meor Azlan, Sunday Solomon Josiah, Jing Zhou, Xiaoxia Zhou, Lingjun Jie, Yanhui Zhang, Cuilian Dai, Dong Liang, Peifeng Li, Zhengqiu Li, Zhen Wang, Yun Wang, Ke Ding, Yan Wang, Jinwei Zhang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2023-12-01
Serie:Journal of Pharmaceutical Analysis
Soggetti:
Cation-chloride cotransporters
Chloride volume regulation
Cotransporter assays
Drug discovery
Accesso online:http://www.sciencedirect.com/science/article/pii/S2095177923002150
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