Elimination of SHIV Infected Cells by Combinations of Bispecific HIVxCD3 DART® Molecules

Bispecific HIVxCD3 DART molecules that co-engage the viral envelope glycoprotein (Env) on HIV-1-infected cells and the CD3 receptor on CD3+ T cells are designed to mediate the cytolysis of HIV-1-infected, Env-expressing cells. Using a novel ex vivo system with cells from rhesus macaques (RMs) infect...

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Autores principales:	Marina Tuyishime, Amir Dashti, Katelyn Faircloth, Shalini Jha, Jeffrey L. Nordstrom, Barton F. Haynes, Guido Silvestri, Ann Chahroudi, David M. Margolis, Guido Ferrari
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2021-08-01
Colección:	Frontiers in Immunology
Materias:	HIV bispecific DART molecules redirected cytotoxicity cytotoxic T cells broadly neutralizing antibodies non-neutralizing antibodies
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.710273/full
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