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Proinflammatory Pathways Are Activated in the Human Q344X Rhodopsin Knock-In Mouse Model of Retinitis Pigmentosa

Retinitis pigmentosa (RP) is a hereditary disease of the retina that results in complete blindness. Currently, there are very few treatments for the disease and those that exist work only for the recessively inherited forms. To better understand the pathogenesis of RP, multiple mouse models have bee...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: T.J. Hollingsworth, Meredith G. Hubbard, Hailey J. Levi, William White, Xiangdi Wang, Raven Simpson, Monica M. Jablonski, Alecia K. Gross
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2021-08-01
Schriftenreihe:Biomolecules
Schlagworte:
retinal degeneration
retinitis pigmentosa
rhodopsin
inflammation
microglia
TNFα, NF-κB
Online-Zugang:https://www.mdpi.com/2218-273X/11/8/1163
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