Atomic resolution cryo-EM structure of a native-like CENP-A nucleosome aided by an antibody fragment
CENP-A histone variants replace histones H3 at centromeres. Here the authors use a single-chain antibody fragment (scFv) to stabilize human CENP-A nucleosome containing a native α-satellite DNA and solved its structure by cryo-EM to 2.6 Å resolution, providing insight into the structure and function...
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| Główni autorzy: | , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Nature Portfolio
2019-05-01
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| Seria: | Nature Communications |
| Dostęp online: | https://doi.org/10.1038/s41467-019-10247-4 |
| Etykiety: |
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