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HOPS: a quantitative score reveals pervasive horizontal pleiotropy in human genetic variation is driven by extreme polygenicity of human traits and diseases

Abstract Horizontal pleiotropy, where one variant has independent effects on multiple traits, is important for our understanding of the genetic architecture of human phenotypes. We develop a method to quantify horizontal pleiotropy using genome-wide association summary statistics and apply it to 372...

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Principais autores: Daniel M. Jordan, Marie Verbanck, Ron Do
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-10-01
coleção:Genome Biology
Assuntos:
Pleiotropy
Polygenicity
Genetic architecture
GWAS
Statistical method
R package
Acesso em linha:http://link.springer.com/article/10.1186/s13059-019-1844-7
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