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The efficacy of the benzimidazoles oxfendazole and flubendazole against Litomosoides sigmodontis is dependent on the adaptive and innate immune system

Filarial nematodes can cause debilitating diseases such as lymphatic filariasis and onchocerciasis. Oxfendazole (OXF) is one promising macrofilaricidal candidate with improved oral availability compared to flubendazole (FBZ), and OXF is currently under preparation for phase 2 clinical trials in fila...

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Principais autores: Frederic Risch, Johanna F. Scheunemann, Julia J. Reichwald, Benjamin Lenz, Alexandra Ehrens, Joséphine Gal, Frédéric Fercoq, Marianne Koschel, Martina Fendler, Achim Hoerauf, Coralie Martin, Marc P. Hübner
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-06-01
coleção:Frontiers in Microbiology
Assuntos:
filariae
Litomosoides sigmodontis
oxfendazole
flubendazole
macrofilaricide
combination therapy
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1213143/full
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