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Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer

Retargeting of T lymphocytes toward cancer cells by bispecific antibodies has demonstrated its therapeutic potential, with one such antibody approved for the treatment of acute lymphoblastic leukemia (blinatumomab) and several other in clinical trials. However, improvement of their efficacy and sele...

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Auteurs principaux: Antonio Tapia-Galisteo, Íñigo Sánchez Rodríguez, Oscar Aguilar-Sopeña, Seandean Lykke Harwood, Javier Narbona, Mariola Ferreras Gutierrez, Rocío Navarro, Laura Martín-García, Cesáreo Corbacho, Marta Compte, Javier Lacadena, Francisco J. Blanco, Patrick Chames, Pedro Roda-Navarro, Luis Álvarez-Vallina, Laura Sanz
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis Group 2022-12-01
Collection:OncoImmunology
Sujets:
trispecific antibodies
single-domain antibodies
scfv
tandem antibodies
cancer immunotherapy
colorectal cancer
Accès en ligne:http://dx.doi.org/10.1080/2162402X.2022.2034355
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