Mechanism of Rad51 filament formation by Rad52 and Rad55-Rad57 in homologous recombination
Abstract Homologous recombination (HR) repairs double-stranded DNA breaks (DSBs) by generating single-stranded DNA (ssDNA), which is initially coated by Replication Protein A (Rpa). Rad51, a recombinase, catalyzes strand invasion but binds ssDNA with lower affinity than Rpa, necessitating mediator p...
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| Huvudupphov: | , , , , , , , , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
Nature Portfolio
2025-07-01
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| Serie: | Nature Communications |
| Länkar: | https://doi.org/10.1038/s41467-025-61811-0 |
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