TYRP1 directed CAR T cells control tumor progression in preclinical melanoma models

Despite therapeutic efficacy observed with immune checkpoint blockade in advanced melanoma, many tumors do not respond to treatment, representing a need for new therapies. Here, we have generated chimeric antigen receptor (CAR) T cells targeting TYRP1, a melanoma differentiation antigen expressed on...

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Hlavní autoři:	Christopher S. Hackett, Daniel Hirschhorn, Meixian S. Tang, Terence J. Purdon, Yacine Marouf, Alessandra Piersigilli, Narasimhan P. Agaram, Cailian Liu, Sara E. Schad, Elisa de Stanchina, Sarwish Rafiq, Sebastien Monette, Jedd D. Wolchok, Taha Merghoub, Renier J. Brentjens
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2024-09-01
Edice:	Molecular Therapy: Oncology
Témata:	MT: Regular Issue melanoma acral uveal chimeric antigen receptor adoptive cellular therapy
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2950329924001048
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