Capsaicin-Induced Endocytosis of Endogenous Presynaptic CaV2.2 in DRG-Spinal Cord Co-Cultures Inhibits Presynaptic Function

Abstract The N-type calcium channel, CaV2.2 is key to neurotransmission from the primary afferent terminals of dorsal root ganglion (DRG) neurons to their postsynaptic targets in the spinal cord. In this study, we have utilized CaV2.2_HA knock-in mice, because the exofacial epitope tag in CaV2.2_HA...

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Detalhes bibliográficos

Principais autores:	Krishma H Ramgoolam, Annette C Dolphin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Physiological Society 2023-01-01
coleção:	Function
Assuntos:	CaV2.2 channels calcium imaging DRG neurons TRPV1 channels protein trafficking rab11
Acesso em linha:	https://journals.physiology.org/doi/10.1093/function/zqac058
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