Tobacco smoke condensate-induced senescence in endothelial cells was ameliorated by colchicine treatment via suppression of NF-κB and MAPKs P38 and ERK pathways activation

Abstract Smoking is the major cause of cardiovascular diseases and cancer. It induces oxidative stress, leading to DNA damage and cellular senescence. Senescent cells increase the expression and release of pro-inflammatory molecules and matrix metalloproteinase, which are known to play a vital role...

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Detalhes bibliográficos

Principais autores:	Dilaware Khan, Huakang Zhou, Jinliang You, Vera Annika Kaiser, Rajiv K Khajuria, Sajjad Muhammad
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-04-01
Colecção:	Cell Communication and Signaling
Assuntos:	Tobacco smoke HUVECs NF-kB MAPKs Senescence SASP factors
Acesso em linha:	https://doi.org/10.1186/s12964-024-01594-x
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