Tetrandrine-based in situ vaccination via multifunctional Mn²⁺-hyaluronic acid hydrogel loading gelatinase-responsive nanoparticles

Abstract In situ tumor vaccination (ISV) has emerged as a promising strategy for converting tumors into endogenous vaccine depots, but its application in breast cancer remains limited by poor intratumoral drug retention and insufficient microenvironment remodeling. Here, we developed an injectable M...

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Principais autores:	Wanru Wang, Shujun Song, Dongliang Han, Yuling Qiu, Dan Lei, Xuxuan Gu, Haoyue Qi, Hanxi Zhang, Lanqi Cen, Jie Shao, Xiaoping Qian, Wenxiu Chen, Lixia Yu, Baorui Liu, Li Xie, Rutian Li
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2026-05-01
Serija:	Journal of Nanobiotechnology
Teme:	Tetrandrine nanoparticles Immunotherapy Injectable hydrogel Sustained release Dual function
Online dostop:	https://doi.org/10.1186/s12951-026-04545-5
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