Tumor detection by analysis of both symmetric- and hemi-methylation of plasma cell-free DNA

Abstract Aberrant DNA methylation patterns have been used for cancer detection. However, DNA hemi-methylation, present at about 10% CpG dinucleotides, has been less well studied. Here we show that a majority of differentially hemi-methylated regions (DHMRs) in liver tumor DNA or plasma cells free (c...

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Autors principals:	Xu Hua, Hui Zhou, Hui-Chen Wu, Julia Furnari, Corina P. Kotidis, Raul Rabadan, Jeanine M. Genkinger, Jeffrey N. Bruce, Peter Canoll, Regina M. Santella, Zhiguo Zhang
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2024-07-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-024-50471-1
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