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Autophagic flux modulates tumor heterogeneity and lineage plasticity in SCLC

IntroductionSmall cell lung cancer (SCLC) is characterized by significant heterogeneity and plasticity, contributing to its aggressive progression and therapy resistance. Autophagy, a conserved cellular process, is implicated in many cancers, but its role in SCLC remains unclear.MethodsUsing a genet...

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Autori principali: Yujie Hao, Mingchen Li, Wenxu Liu, Zhenyi Ma, Zhe Liu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2025-01-01
Serie:Frontiers in Oncology
Soggetti:
autophagic flux
small cell lung cancer
SCLC
lineage transition
heterogeneity
plasticity
Accesso online:https://www.frontiersin.org/articles/10.3389/fonc.2024.1509183/full
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